Student Project 1

Title

Influence of counterion choice (salt selection) on structural and material properties of crystalline compounds

Description

Recently, we studied - in collaboration with DSM and the department of Organic Chemistry - the selective complexation of cephalosporin antibiotics. Detailed investigation of intermolecular interactions in the solid state was the key to the discovery of new, environmentally friendly complexing agents. For new systems, the challenge is to develop an equally detailed picture of relevant interactions leading to "molecular recognition" in the solid state. The final purpose is prediction and rational design of crystalline materials with well-defined structural and physical properties.
In this project the influence of counterion choice on structural and material properties of crystalline compounds is investigated. The project covers both fundamental studies and practical applications of co-crystallization.

Keywords

Salt selection, crystallization, crystal engineering, database analysis, structure analysis, X-ray diffraction, programming

Research program

Chemical Crystallography: Crystal Engineering

Contact person

When you are interested in this student project please contact:

[Icon: mailto Rene]  R. de Gelder    Phone 52842    Room N4018

References

  1. Induced Fit Phenomena in Clathrate Structures of Cephalosporins.
     G.J. Kemperman, R. de Gelder, F.J. Dommerholt, P.C. Raemakers-Franken, A.J.H. Klunder, and B. Zwanenburg.
    Journal of the Chemical Society-Perkin Transactions 2 (2000), 7, 1425-1429.

  2. Cavities, Layers and Channels in the hosting framework of molecular complexes derived from Cephradine.
     G.J. Kemperman, R. de Gelder, F.J. Dommerholt, P.C. Raemakers-Franken, A.J.H. Klunder, and B. Zwanenburg.
    European Journal of Organic Chemistry (2001), 3641-3650.

  3. Molecular selectivity and cooperativity in clathrate-type complexation of Cephradine.
     G.J. Kemperman, R. de Gelder, F.J. Dommerholt, A.J.H. Klunder, and B. Zwanenburg.
    European Journal of Organic Chemistry (2002), 345-350.

  4. Fluxional [(N3)MI(1,5-cyclo-octadiene)]+ (M=Rh, Ir): A Structure Correlation Analysis.
    R.J.N.A.M. Kicken, R. de Gelder, P.H.M. Budzelaar, and A.W. Gal.
    In preparation for Acta Crystallographica B.