(+/-)-schefflone: a trimeric monoterpenoid from the root bark of Uvaria scheffleri
Nkunya MHH, Jonker SA, de Gelder R, Wachira SW, Kihampa C
PHYTOCHEMISTRY 65 (4): 399-404 FEB 2004

Abstract:
The trimeric monoterpene and mildly mosquito larvicidal agent, (+/-)-schefflone, that is an apparent derivative of the antiparasitic aromatic monoterpene espintanol, was isolated from the antimalarial extracts of the root bark of Uvaria scheffleri, together with espintanol. Structural determination of ()-schefflone was achieved from spectroscopic data and confirmed by single-crystal X-ray diffraction analysis. (+/-)-Schefflone can be considered a product of a non-enzymatic Diels-Alder-type cycloaddition reaction of the quinonemethide derivative of espintanol as the diene and dienophile.