Pd-catalysed synthesis of 5-substituted proline derivatives from acetylene-containing amino acids
van Esseveldt BCJ, van Delft FL, Smits JMM, de Gelder R, Rutjes FPJT
SYNLETT (15): 2354-2358 DEC 1 2003

Abstract:
2,5-Disubstituted pyrrolines have been synthesised via Pd-catalysed 5-endo-dig cyclisations of substituted acetylene-containing amino acids. It has also been shown that these pyrrolines can be efficiently transformed into the corresponding saturated proline derivatives.