Diastereoselective zinc-mediated Barbier-type allylation and propargylation of 3-formylcephalosporins
Keltjens R, Vadivel SK, de Gelder R, Klunder AJH, Zwanenburg B
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(9): 1749-1758 MAY 2003


Abstract:
We describe the allylation and propargylation of 3-formylce-phalosporins under zinc-mediated, aqueous Barbier conditions, from which the corresponding homoallylic alcohols are produced in good yields and with good-to-excellent diastereoselectivity.